The UW Medical Cyclotron Facility Target Handling System is comprised of a patent pending target station capable of automatic loading and ejecting of targets, a fully shielded hot cell in lab space outside of the cyclotron vault, and a pneumatic transfer system that shuttles radioactive targets unidirectionally from the station to the hot cell for processing. Prior to this system, targets were manually removed from the beamline and the chemical processing performed in a glove box – a workflow that limited production capacity to activity levels that could be safely handled in this way. The new system allows for significantly higher activity to be produced while lowering the overall exposure to personnel at all points in the production workflow. This advancement to our facility will support phase 2 of multiple, very promising, isotope development initiatives. Support for this upgrade was provided in part by the US Department of Energy Isotope Program, managed by the Office of Science for R&D and Production (DE-SC0019197; DE-SC0013618).